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Category Gandhian Young Technological Innovation (GYTI) Awards, 2017
 
Abstract Dr. R. A. Mashelkar, Chairperson, NIF and the Chair of the Advisory Committee of AASTIIK and SRISTI, chaired the award function and inspired students along with Dr. K. Vijay Raghavan, Secretary, DBT, Dr. Anil Sahasrabuddhe, Chairman, AICTE, Dr. Renu Swarup, MD, BIRAC. Guest of Honour Dr. Francis Gurry, Director General, WIPO, Geneva gave away the awards and also shared his vision about what makes some nations great in innovation while others get left behind. SRISTI and HBN appreciate the efforts of hundreds of faculty members in India and abroad, executives from leading tech companies for reviewing 2,715 nominations from 308 Institutions & Universities, from 27 states & two Union Territories, India in 54 different subject disciplines. This time 22 innovations were selected for award and another 17 for appreciation.
 
Details White Light Emission from Vegetable ExtractsDr. Vikram SinghGuide: Prof. Ashok Kumar MishraIndian Institute of Technology, MadrasWhite light emission (WLE) is generated from natural dyes extracted in the laboratory using a green and simple procedure. The colour temperature of the WLE is conveniently tunable by simply adjusting the concentrations of the component emitters. The primary emitting pigments responsible for contributing to WLE are polyphenols and anthocyanins from pomegranate, and curcumin from turmeric. WLE from such cheap and nature friendly resources could be important in the context of lighting and sensing application. It would be interesting to see if such a system can be used as dyes for tunable dye laser applications.WLE biomaterials with ease of adjusting colour temperature, which will obviate more expensive alternatives currently being pursued.http://gyti.techpedia.in/project-detail/white-light-emission-from-vegetable-extracts/7414A Virtual Reality (VR)-based Immersive Simulator for Endoscopy TrainingShanthanu ChakravarthyGuide: Prof. G. K. AnanthasuresIndian Institute of Science, Bengaluru Virtual Reality (VR) together with haptics offers an immersive and flexible platform for training doctors in medical procedures. In this project, a VR-based endoscopy simulator together with the force-feedback system is developed.Endoscopy is minimally invasive and is used as an important diagnostic tool to detect abnormal tissues, ulcers, tumours, polyps, cancers, etc., Gastrointestinal (GI) endoscopy, including colonoscopy, is a complex procedure involving a high degree of hand-eye coordination. These procedures are generally carried out by highly skilled surgeons. In order to practice endoscopy safely, a training system that does not involve patients is deemed important. VR-based training system developed in this work has many advantages. The endoscopy simulator developed in this project has the potential for extension to other interventional procedures such as colonoscopy, bronchoscopy, and endovascular training.http://gyti.techpedia.in/project-detail/a-novel-virtual-reality-vr-based-immersive-simulator-for-endoscopy/7710Rotary Ultrasonic Bone DrillingDr. Vishal GuptaGuide: Prof. Pulak Mohan PandeyIndian Institute of Technology, DelhiThere is always a necessity to minimise the magnitude of drilling force and torque during the bone drilling process. To minimise the rise in temperature, force and torque during surgical bone drilling process for more efficient and successful orthopaedic and trauma surgery, a novel bone drilling technique i.e., rotary ultrasonic bone drilling named as RUBD has been successfully developed. It also minimizes micro-cracks during bone drilling. It was also found that RUBD generated a much lower temperature, force and torque as compared to the CSBD.http://gyti.techpedia.in/project-detail/rotary-ultrasonic-bone-drilling/7768A Novel Hybrid System For Textile Dye Waste Water TreatmentBhaskar BethiGuide: Dr. Shirish Hari SonawaneNational Institute of Technology, Warangal Ultrasonic irradiation is used to initiate the emulsion polymerisation to form hydro- gel through the generation of free radicals as well as the uniform distribution of clay across the hydro gel polymer matrix. These are a new class of composite materials, which combine elasticity and permeability of the gels with high ability of the clays to adsorb different substances. The developed hybrid system for the treatment of dye waste water can be easily scaled up to industrial scale for the treatment of bulk volume of textile wastewater. This innovative technology mainly involves unique feature of both the degradation and subsequent absorption of dye organic pollutants from the waste water in a single set of unit.http://gyti.techpedia.in/project-detail/novel-hybrid-system-for-textile-dye-wastewater-treatment/7871Dual Functional Characteristics of Escherichia Coli Outer Membrane Protein Wzi And Its Implications In The Design Of Novel AntibioticsShivangi Sachdeva, Narendar KolimiGuide: Dr Thenmalarchelvi RathinavelanIndian Institute of Technology, HyderabadThe emergence of multidrug resistance in bacteria is an increasingly important cause of infection and mortality worldwide. In Gram-negative bacteria, polysaccharide layers are one of the major viru lent determinants that are involved in the evasion of host immune response as well as offers impermeability to antibiotics. Thus, inhibiting the capsular polysaccharide (CPS) biogenesis or surface exportation or its attachment to the bacterial surface may be an attractive strategy to generate a virulent Gram-negative bacterial strain. Here, the focus is on multidrug resistant Gram-negative Escherichia coli, which is a common cause for urinary tract infections (including infections in the kidney), bloodstream infection, intra-abdominal infections such as peritonitis, skin and soft tissue infections, neonatal meningitis, diarrhoea and food borne infections. The dual functional role of Wzi was not realised earlier due to the occluded pore, a property that can be used to treat E. coli infections. http://gyti.techpedia.in/project-detail/revealed-dual-functional-characteristics-of-escherichia-coli-outer-membrane-protein/7923Targeted Theranostic Nanomedicines For Brain Cancer TherapySonali Singh Doharey, Rahul Pratap Singh, Poornima AgrawalGuide: Dr. M. S. Muthu, Prof. B. L. PandeyBanaras Hindu University, VaranasiChemotherapy is the most common method for the treatment of different types of brain cancers. Unfortunately, the diagnosis and therapy of brain cancer are very unsatisfactory because of the existence of the blood-brain barrier (BBB), which excludes more than 98% of small molecules and almost 100% of large molecules. Another obstacle in cancer therapy is to maintain the desired concentration of therapeutic agents and/or diagnostic agents at tumor site.The innovators demonstrated that RGD or transferring TPGS decorated theranostic liposomes were highly effective in delivering desired concentration of therapeutic agents and diagnostic agents across BBB without any signs of brain damage or oedema in brain histopathology. These advanced platforms can diagnose brain cancer at early stages, initiate first-line therapy, monitor it, and if needed, rapidly start subsequent treatments. In future, brain theranostics will be able to provide personalized treatment which can make brain cancer even curable or at least treatable at the earliest stage.http://gyti.techpedia.in/project-detail/targeted-theranostic-nanomedicines-for-brain-cancer-therapy/8327Blood Quality Assessment using Digital Holographic MicroscopyMandeep Singh, Azhar Muneer Guide: Dr. Kedar Khare and Dr. Sarita AhlawatIndian Institute of Technology, DelhiThe stored blood in blood banks is used regularly in surgical procedures or transfusions. Current blood quality assessment protocols involve a number of chemical assays or impedance measurements making the process cumbersome and difficult to standardise. A superior DHM technology for accurate high resolution 3D imaging of biological cells for blood cell classification and quality assessments been developed. DHM operates on the principle of interference of light and can provide accurate information regarding minute refractive index changes in the cells that are ultimately related to cellular changes in response to ageing, physical cell damage or infections. Using the novel 3D imaging capability of this prototype system has indicated that fresh and old red blood cells have clearly distinguishable morphological features.http://gyti.techpedia.in/project-detail/blood-quality-assessment-using-digital-holographic-microscopy/8332STERI-FREEZ: Flash Freeze SterilisationSaugandha Das, Institute of Chemical Technology, Mumbai and Archit Devarajan, Ramnivas Ruia Junior College, MumbaiGuide: Prof. Padma V. DevarajanSurgical site infections are one of the most common complications associated with surgery, with reported incidence rates of 2-20%. About one-third of surgical patients get infected in developing countries, of the various causes, the use of contaminated medical instruments that have not been properly cleaned and sterilised. STERI-FREEZ provides a simple on-site technology, which provides a ready to use, economic yet effective solution to the existing lacunae. This portable, cold sterilisation device comprises an insulator box housing a metallic vessel covered with a lid containing a green cryogenic biocidal mixture or Flash Freeze Elixir (FFE). Sterilisation is achieved using a combination of biocides acting at subzero temperatures (-70 degree Celsius). Surgical instruments to be sterilized are kept immersed in FFE and removed just prior to use without leaving any toxic residue on the surfaces. Conventional methods of medical sterilisation (autoclave, hot air, chemical and ( gaseous sterilisation) require energy intensive instruments and long processing time while alternative sterilisation techniques (Boiling in water) are not considered effective enough.http://gyti.techpedia.in/project-detail/steri-freez-flash-freeze-sterilization/8374Prophylactic Transdermal Patch Against Neurotoxin Poisoning In Biological Warfare SituationsSubham Banerjee Guide: Dr. Pronobesh Chattopadhyay, Dr. Animesh GhoshDefense Research Laboratory, Tezpur, Birla Institute of Technology, MesraDrug-in-adhesive matrix type combinational prophylactic transdermal patch has been developed. It includes eserine and pralidoxime chloride (PAM) against acetyl choline agonist (±)-anatoxin a neurotoxin poisoning. Initially, a simple RP-HPLC method was developed and validated for the simultaneous determination and quantification of eserine and 2-PAM using UV detection. The method was validated as per ICH guidelines for validation of analytical procedures, and was applied for the routine analysis of these two drugs in fabricated transdermal patches. From safety point of view, the optimised transdermal patch was safe for application to the skin with no dermal and mutagenic toxicity as well. Pharmacodynamic study proved that it was effective against acetyl choline agonist(±)-anatoxin a neurotoxin poisoning. While pharmacokinetic study revealed that the systemic absorption of the drugs from the fabricated best optimised patch through the skin was sufficient enough to achieve pharmacodynamic efficacyhttp://gyti.techpedia.in/project-detail/prophylactic-transdermal-patch-against-neurotoxin-poisoning-in-biological-warfare-situations/8446Low Cost and Field-Portable Smartphone Platform Water Testing Kit for Detection and Analysis of Contaminants in Drinking WaterIftak Hussain, Dr. Kamal Uddin Ahamad Guide: Dr. PabitraNathTezpur University, TezpurMore than three core household are using drinking water contaminated with excess iron, followed by fluoride, salinity and nitrate. Most of the detection methods for water contamination are confined to laboratory due to time-consuming measurement procedure and the use of bulky instruments such as spectrophotometer in colorimetric tests.In the present invention, the smartphone is converted into a laboratory grade low-cost, robust and field portable water quality monitoring kit to detect and quantify water contaminants such as fluoride, turbidity and salinity. Using the same kit, all the colour based water quality monitoring can be possible. The illumination sensor or ambient light sensor (ALS) of the smartphone is used as a detector and its optical led flash is used as a light source to convert the smartphone in to a photometric sensor for its utilisation in water quality monitoring.http://gyti.techpedia.in/project-detail/low-cost-and-field-portable-smartphone-platform-water-testing-kit/8576Near Infrared Fluorescence Probes for Diagnosis of Alzheimer’s diseaseK. Rajasekhar, Kavita Shah Guide: Prof. T. GovindarajuJawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru Selective detection and staining of toxic amyloid beta (A²) plaques found in the Alzheimer’s disease (AD) brain is crucial for clinical diagnosis and monitoring of the disease progress. Herein, a coumarin-quinoline (CQ) conjugate-based molecular rotor type, turn-on near-infrared (NIR) fluorescence probe for selective and specific detection of A² fibrillar aggregates is designed. Remarkably, CQ unambiguously stains A² plaques in human brain tissue over its co-existing Tau aggregates, neurofibrillary tangles (NFTs), which are strongly associated in AD and in various tauopathies. This is a highly desirable attribute to distinguish AD from disease conditions caused by Tau pathology.http://gyti.techpedia.in/project-detail/near-infrared-fluorescence-probes-for-diagnosis-of-alzheimer-s-disease/8577Low-Cost Automated Handheld Melamine Detection Device (for Testing Melamine in Milk)Dhiraj Indana, S.C.G. Kiruba Daniel, Varun S, Prateek Katare Guide: Dr. Sai Siva GorthiIndian Institute of Science, Bangalore Even though a number of kits and devices are available for detecting common milk adulterants like urea, boric acid, water, sugar and detergents, there is hardly any portable device available for the detection of melamine. Currently, bulky instruments like Gas Chromatography (GC), HPLC, GC-MS and LC-MS are used for detecting melamine. These costs approximately 25 to 50 lakh rupees, besides skilled personnel for operation. A fully automated handheld device to detect melamine from milk with integrated milk pre-processing step using chemical dried cotton is developed. Melamine is finally detected through interference in silver nano particle formation. Both the pre-processing and detection steps are innovative and patented. The cost of the device may be few thousand rupees. This device fulfils the goal of taking melamine sensing to every household so as to save people from melamine adulteration.http://gyti.techpedia.in/project-detail/low-cost-automated-handheld-melamine-detection-device-for-testing-melamine/9171NeuroBuds: Brain Wave Mapping Smart Earphones for Rural IndiaNitin Vasanth Guide: Prof. Unni A MCochin University of Science & Technology, Cochin An average human brain consists of over 80 billion neurons. These communicate with each other by sending short ionic impulses, which in turn creates small voltage fluctuations around the proximity of brain. By placing highly sensitive sensors, these fluctuations can be used to understand the brain activity. NeuroBuds is a pair of smart earphones that have these specially fabricated sensors embedded into it to understand the brain activity of user. The brain data is analysed to look for anomalies in pattern that indicate brain disorders like epileptic seizures. This kind of early detection helps in doing pre-emptive action and sending out alerts. The brain wave data is also used to analyse the mental state of the user, their concentration levels and stress levels. At a time when lot of people suffer from stress related issues and sleeping disorders due to a fast-paced lifestyle, NeuroBuds can be used as a mental health monitor. Once the application has enough data coming in from different users, it can recognize patterns and optimise algorithms on its own using the underlying neural network. NeuroBuds serves as the perfect link between the user and the smartphone to monitor other body vitals including heartbeat.http://gyti.techpedia.in/project-detail/neurobuds-brain-wave-mapping-smart-earphones/9228Affordable and Rapid Paper-based Test Kits for Antimicrobial Susceptibility AssaysShantimoy Kar, arun Agarwal, Shubhanath, Behera, Varun Varma Guide: Dr. Suman Chakraborty, Prof. Tapas K. MaitiIndian Institute of Technology, Kharagpur Increasing drug resistance of the pathogenic microbes is a global threat to the human mortality. To meet this challenge, there is a need to develop a rapid antimicrobial susceptibility testing platform. The current techniques are time consuming, labour intensive, require sophisticated infrastructure and skilled personnel. This collectively increases the overall cost of the diagnosis. A simple paper based microfluidics platform for easy and rapid execution of antimicrobial susceptibility assays is developed. The device consists of a paper-based platform which includes four different layers: a base layer, a bacterial suspension layer, a drug layer and a top layer containing a chromogenic substrate which changes color in accordance to the bacterial metabolic activities. The developed technology provides faster detection (
 
Volume No. Honey Bee 28(1) 15-22

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